+359 87 700 003932 Elemag St., Izgrev District, 1113 Sofia, BulgariaMonday – Friday · 09:00–17:00
Cell technologies

Small scale.
Close attention.

Learn about the cell-based approaches, their applications, limitations and scientific basis. The specific options are discussed with a doctor.

Clinic and laboratory
Translucent cell-like form — artistic image
01Endogenous pluripotent stem cells

MUSE cells

MUSE cells (Multilineage-differentiating Stress Enduring cells) are a rare population of naturally occurring stem cells found within mesenchymal stem cell populations. They were first identified by Professor Mari Dezawa and her research team in Japan and have since been the focus of extensive international research.

Unlike conventional mesenchymal stem cells, MUSE cells possess characteristics associated with pluripotent stem cells while maintaining a favourable safety profile. They are being studied for their ability to migrate to damaged tissues and take part in repair processes.

Their potential role in specific conditions requires further scientific and clinical evaluation. Applicability in your case is discussed with a doctor.

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02MSCs from the amniotic membrane of the placenta

Mesenchymal stem cells

Mesenchymal stem cells (MSCs) are multipotent structures that can differentiate into various types of connective tissue cells. The amniotic membrane is the inner layer of the placenta that surrounds the foetus during pregnancy; it is rich in mesenchymal stem cells with a high potential for tissue repair.

Characteristics: high proliferative capacity, multipotency, anti-inflammatory and immunomodulatory properties, low immunogenicity. Obtaining cells from the amniotic membrane does not require invasive procedures and harms neither the mother nor the child.

Placental MSCs are regarded in regenerative medicine as a tool with regenerative properties and a good safety profile.

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03Nano-sized extracellular vesicles

Exosomes

Exosomes are a subgroup of nanosized extracellular vesicles secreted by cells that play an important role in intercellular communication. They contain biologically active molecules (proteins, lipids, microRNAs and growth factors) that influence regenerative processes in the body.

Features: regenerative signalling, an anti-inflammatory effect, minimal risk of rejection (exosomes do not contain a cell nucleus) and the ability to enhance the effect of stem cell therapy when administered together.

Researchers are actively studying the potential of exosomes in regenerative medicine and the possibilities for personalised therapy.

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Biotechnology laboratory

Quality standards at the cellular level.

The laboratory is designed and equipped in accordance with international GMP (Good Manufacturing Practice) standards, which ensure safety, sterility and precision at every stage of work with biomaterial.

  • isolation, cultivation and cryopreservation of stem cells while preserving their viability;
  • epigenetic and cellular analysis to assess biological age and the condition of the body;
  • development and application of personalised cell protocols.

Every procedure – from collection to application – undergoes strict laboratory control. GMP and ISO 9001 standards and the European requirements for working with biological material are observed.

Patient room at STEM PLUS
Reception desk at the STEM PLUS clinic
Procedure at the STEM PLUS clinic
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